Abstract
The developmental changes in the activity of 85 kDa calcium-dependent cytosolic PLA2 in pre-term embryonic rat brain and in primary cultures of rat cortical neurons has been assessed with the aid of a radio-enzymatic method. We have further investigated the modulation of the enzymatic activity in primary cortical neurons, namely the inhibition of PLA2 with MAFP and the activaton with mellitin.
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