Abstract
Mammalian cells contain several structurally different phospholipase (PLA 2) enzymes that exhibit distinct localisation, function and mechanisms of regulation. PLA 2 isozymes have been postulated to play significant roles in the parturition process. Both secretory and cytosolic PLA 2 isozymes have been identified in human gestational tissues, and there is differential expression of these PLA 2 isozymes in human fetal membranes and placenta obtained at preterm and term. The aims of this commentary are: (1) to review recent data concerning the expression, role and regulation of PLA 2 isozymes in human gestational tissues; and (2) to present novel data demonstrating the regulation of PLA 2 isozymes in human gestational tissues by nuclear factor-kappa B (NF- κB) and peroxisome proliferator-activated receptor (PPAR)-g.
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