Abstract
The effect of human serum albumin (HSA) on the hydrolysis of phosphatidylinositides in human platelets labeled with myo( 3H)inositol was studied. Incubation of platelets with HSA (4 gm/dl) for 10 seconds increased IP 2 and IP 3 by 169% and 217% respectively. 93% of IP 3 accumulated within the first 10 seconds. This effect was also shared by bovine serum albumin, although no changes in IP 3 levels occured with ovalbumin. All albumin species used induced 45Ca +2 release from platelets irrespective of its effect on IP 3 accumulation. These findings indicate that albumin may function in biological systems by inducing intracellular signaling.
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