Abstract
BackgroundHeart failure (HF) is a serious and advanced stage of various cardiac diseases with high mortality and rehospitalization rates. Phosphoglycerate mutase 2 (PGAM2) overexpression was identified in the serum of patients with HF.Material/methodsOne hundred and fifty-three cases of HF were included in the present work. According to New York Heart Association (NYHA) classification, 22 were grade II, 84 were grade III, and 47 were grade IV. Serum PGAM2, NT-proBNP, B-type natriuretic peptide (BNP), troponin T (TNT), and Cys-C of HF patients were detected using ELISA assay. Left ventricular ejection fraction, left ventricular end-diastolic inner diameter, and left atrium (LA) inner diameter of the included cases were also detected by the cardiac color Doppler.ResultsThe number of patients with atrial fibrillation was significantly higher in NYHA IV group than in groups II and III with statistical difference (p < 0.05). The serum PGAM2, NT-proBNP, and Cys-C were significantly higher in NYHA IV group than in NYHA II and NYHA III groups (p all < 0.05). NT-proBNP had the highest prediction efficacy of HF severity and PGAM2 was also a potential biomarker for HF severity evaluation with relatively high sensitivity, specificity, and area under the ROC. The overall survival among NYHA II, III, and IV groups were statistically different (p = 0.04) with the median survival time of 25 months for NYHA III and IV groups.ConclusionPGAM2 is a new promising biomarker for evaluation of the severity of HF. Combination detection using multiple serum factors such as PGAM2, NT-proBNP, BNP, TNT, and Cys-C can improve the HF severity differential diagnosis performance.
Highlights
Heart failure (HF) is a disease with poor prognosis and frequent occurrence [1,2,3]
Color Doppler ultrasound was used to measure the patients’ left ventricular ejection fraction (LVEF), left ventricular end-diastolic inner diameter (LVEDD), left atrium (LA) inner diameter, and other indicators, as Venous blood specimens were collected on the morning of the second day after admission or on the day of physical examination and sent to the biochemistry room of Jinan Central Hospital for examination and serum level of Phosphoglycerate mutase 2 (PGAM2), T-proBNP, B-type natriuretic peptide (BNP), troponin T (TNT), and Cys-C were detected
Our results confirmed increased PGAM2 levels in the blood of HF patients; more importantly, our study reveals for the first time that PGAM2 is a good biomarker for HF diagnosis
Summary
The severity and prognosis of various biomarkers for HF have been widely discussed, including B-type natriuretic peptide (BNP), NT-proBNP [4,5,6], neutrophils gelatinase-related lipid calin [7], soluble ST2, troponin, central preadrenal medlin, copeptin, chromogranin A, and S100B protein [8]. The accuracy of BNP in diagnosing chronic HF and acute decompensated HF has been widely assessed and specific boundaries established, the BNP test is subject to limitations that may challenge its interpretation. These included values in the middle gray area and explained subtle differences in levels of renal dysfunction, obesity, and advanced age.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
