Abstract
An efficient technique is presented which integrates cofactor dependent enzymic phosphorylation and dehydrogenation into a single, closed-loop system by employing phosphoenolpyruvate as the sacrificial reagent for sequential ATP and NAD + recycling steps. Exemplary applications are developed for the synthesis of 6-phosphogluconate from glucose, and that of dihydroxyacetone phosphate from glycerol. The latter system is combined with exergonic diastereoselective aldol additions for the one-flask synthesis of a ketosugar ( d-sorbose), thiosugar ( l- threo-5-thiopentulose), or a sugar acid ( l- threo-pent-4-ulosonic acid) starting from a mixture of glycero simple aldehydes.
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