Abstract
A single, post-trial injection of the phosphodiesterase inhibitors Ro-20-1276 (25 and 50 mg/kg) or isobutylmethylxanthine (IBMX, 75 mg/kg) enhanced the retention of a one-trial passive avoidance response in male ICR mice. This performance enhancement was not seen when the injection was given 1 hr following task acquisition, and no-footshock controls did not have lengthened step-through latencies at retention testing, suggesting that these drugs facilitated memory formation. At a low dose, post-trial IBMX (25 mg/kg) significantly impaired performance. These results are similar to those we have previously reported for papaverine, and suggest that cyclic nucleotides may play a role in memory formation.
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