Abstract
Herein, a new approach for the synthesis of (Z)-N-alkenyl-2-pyridones from 2-pyridones and propiolates using phosphine catalysis under mild conditions is reported. This dual Z-diastereoselective and N-selective reaction demonstrates excellent selectivity, yielding sole (Z)-N-alkenyl-2-pyridones. Furthermore, scale-up studies confirm its practical applicability, with consistent efficiencies observed.
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