Abstract
The tandem addition-cyclization reaction between o-alkynylbenzaldehyde and nucleophile catalyzed by P4- t Bu, a phosphazene base, is demonstrated. The nucleophilic cyclization is efficiently triggered not only by alcohols, including sterically demanding ones, but also by nitrogen nucleophiles, such as amide and pyrrole, under the influence of a catalytic amount of P4- t Bu. The method enables efficient access to isobenzofuran derivatives under mild conditions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
