Abstract
A possible direct renal effect of thyroid hormone was investigated by administering 1.0 mg 3,5,3' l-triiodothyronine (T3) to normal dogs, and measuring the excretion of calcium, phosphorus, magnesium, creatinine and nitrogen for 4 1/2 hours thereafter. In contrast to controls, a pronounced rise in urinary phosphorus regularly followed T3. Renal clearance of phosphorus increased, and tubular reabsorption fell to a mean of 68% of the filtered phosphorus load. A similar response occurred in dogs without parathyroid glands. No increase in calcium, magnesium or nitrogen excretion accompanied the acute phosphaturesis. These results indicate a direct action of triiodothyronine on the renal tubule independent of the level of parathyroid activity.
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