Abstract
Previous studies have put forth a hypothesis that circulating phosphaturic factor (s) exist, and these factor (s) are generically called "phosphatonin" . Through the studies of patients with hypophosphatemic rickets/osteomalacia, FGF23 has emerged as an important candidate for phosphatonin. Discovery of FGF23 as an essential regulator of phosphate homeostasis has markedly improved our understanding of phosphate homeostasis and hypophosphatemic disorders. Elucidation of the mechanism of action of FGF23 as well as the role of PHEX on the development of FGF23 actions should further strengthen our knowledge on the regulation of phosphate homeostasis and pathogenesis of rickets/osteomalacia.
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