Abstract
Chapter 1: Introduction 1 1.1. The Drosophila melanogaster genome 1 1.2. 진핵생물의 protein phosphatases 2 1.3. Protein Ser/Thr phosphatases 3 1.4. Protein Tyr phosphatases 5 1.5 Asp-based protein phosphatases 6 Chapter 2: Materials and Methods 7 2.1 Identification of protein phosphatase 7 2.2 Determination of open reading frame sequence 7 2.3 Finding protein phosphatase domain architecture 7 2.4 Structure modeling, alignment and clustering 8 2.5 Finding orthologous protein phosphatases in other species 8 2.6 Predication of subcellular localization 8 Chapter 3: Results 9 3.1. Protein phosphatases in the Drosophila melanogaster genome 9 3.2 Asp-based protein Phosphatases 11 3.3 Protein Ser/Thr Phosphatases 13 3.3.1. Metallophos family 15 3.3.2. PPM family 17 3.3.3 PPP family 19 3.4 Protein Tyr Phosphatases 21 3.4.1. Classical PTP family 22 3.4.2. DSPP family 24 3.4.3. CDC and LMWPTP 27 3.5 Sub-cellular localization studies 28 3.6 Structure modeling and clustering 29 3.7 Domain architecture 31 Chapter 4: Discussion 34 Chapter 5: References 35
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