Abstract
1. 1. Guanylate cyclase activities of human lymphocyte membrane and cytosol preparations are stimulated up to three-fold by the direct addition of phosphatidylserine. 2. 2. Phorbol 12-myristate 13-acetate (PMA) greatly augments the effect of phosphatidylserine, but has only a small effect when added alone. 3. 3. Stimulation involves an increase in V max, with no change in K m. 4. 4. Inhibitor studies suggest that stimulation may be mediated by protein kinase C, but not by phospholipase or lipoxygenase.
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