Abstract
Summary Proteolipids were detected in lipid extracts of rat liver mitochondria, microsomes and 100,000 xg soluble fraction. In view of the rapid transbilayer movement of phosphatidylcholine in liver microsomal membranes the possible action of microsomal proteolipids as mediators of phospholipid transmembrane movement was investigated. Single bilayer lipid vesicles were prepared by sonication or by a cholate dispersion technique from either total or proteolipid-free lipid extracts from microsomes. Accessibility of phosphatidylcholine in these membranes to a specific phosphatidylcholine exchange protein was restricted to the amount located in the outer monolayer of the vesicles.
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