Abstract
Abstract: The study describes the use of a, b, and g phosphated cyclodextrins. .CDs for chiral separation by capillary electrophoresis CE . A systematic studywas performed to establish the effect of such variables as the type and concentra-tion of chiral selectors as well as the pH and ionic strength of buffer and organicmodifiers. It was found that CDs with acidic character offer high chiral selectivitytoward basic compounds. These CDs can give chiral recognition features towardmolecules in their ionized as well as in their undissociated form. The phosphatedcyclodextrins were also found to have adsorptive properties resulting in mixed-migration mechanism, and some guidelines are given to avoid this side effect. Anumber of racemic drug molecules were used as model compounds to demonstrateoptimization procedures of the competing parameters in the analysis. Q 1997 JohnWiley & Sons, Inc. JMicroSep 9: 581]589, 1997 Key words: chiral separation; phosphated cyclodextrins; capillary electrophoresis
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