Phosphate Is a Uremic Toxin

Abstract

Hyperphosphatemia is one of the more prevalent metabolic disturbances in kidney failure. Phosphate can be considered a uremic toxin based on the accumulation of phosphate during chronic kidney disease, the effects of phosphate on biological systems, and the adverse effects of hyperphosphatemia. The renal clearance of phosphate is maintained until later stages of chronic kidney disease, when the remaining nephrons are no longer able to excrete sufficient phosphate to offset dietary phosphate absorption. Clearance of phosphate by conventional forms of dialysis is insufficient to prevent hyperphosphatemia in most endstage kidney-disease patients. Phosphate contributes to metabolic disturbances such as hyperparathyroidism, vitamin D resistance, and hypocalemia. In combination with these and other factors, hyperphosphatemia damages many organs, including the parathyroid glands, bones, and most importantly the cardiovascular system. Elevated phosphorus is associated with arterial and valvular calcification, arteriosclerosis, and an increased risk of cardiovascular death. Importantly, the adverse effects of hyperphosphatemia are partially preventable with the effective treatments available today.