Abstract
Previous studies have shown that, in the intact mouse, tourniquet trauma decreases the concentration of liver glutathione as well as the ability of the liver to synthesize GSH† after cysteine injection. Prior administration of bromobenzene also decreases liver GSH, but does not decrease GSH synthesis by the liver after cysteine injection. Since the literature indicates that trauma induces depletion of tissue ATP required for GSH synthesis, the present work attempted to study the relationship between liver ATP concentration and the liver's potential for GSH synthesis. In the present experiments the trauma procedure used induced significant increases in liver ATP, whereas bromobenzene preadministration resulted in decreases in liver ATP. Hence, over-all liver ATP concentration does not appear to be limiting for GSH synthesis in trauma. Similar ATP/ADP ratios were obtained for livers of control, traumatized, and bromobenzene-treated mice. Inorganic phosphate and total acid-soluble phosphate were elevated after trauma; total acid-soluble phosphate was depressed after bromobenzene administration.
Published Version
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