Abstract
Prolactin and phorbol myristate acetate (TPA) stimulate the rate of [3H]uridine incorporation in cultured mouse mammary gland explants in a similar fashion. Both the time-courses and magnitude of responses were the same; in addition, maximum stimulatory concentrations of TPA and prolactin elicited a nonadditive response when tested together. Nordihydroguaiaretic acid (NDGA), a lipoxygenase inhibitor, abolished both the TPA and prolactin effects on [3H]uridine incorporation. TPA also effected an enhanced rate of [3H]leucine incorporation into a casein-rich phosphoprotein fraction, but only if the explants were also cultured with spermidine.
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