Abstract
Summary Tumor promoting phorbol esters, at nM concentrations, rapidly stimulate Na + entry into intact 3T3 cells incubated in the presence of ouabain. The effect is specific and time and dose-dependant. In the absence of ouabain phorbol esters increase Na-K pump activity. Since stimulation of Na-K pump activity by TPA is i) dependant on the Na + concentration in the medium ii) abolished by the sodium ionophore monensin, we suggest that the phorbol esters stimulate Na-K pump activity by increasing Na + influx into 3T3 cells.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
