Abstract
The effect of 12- O-tetradecanoylphorbol-13-acetate (TPA) on serotonin-induced inositol phosphate (IP) accumulation and intracellular free Ca 2+ concentrations ([Ca 2+] i) was investigated in cultured rat vascular smooth muscle cells. Pretreatment with TPA had no effect on basal levels of both IP production and [Ca 2+] i, whereas it significantly attenuated serotonin-induced increases in both IP production and [Ca 2+] i. These data suggest that protein kinase C is involved in the negative feedback control of serotonin-induced rises in both IP production and [Ca 2+] i.
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