Abstract
Ivermectin delivered continuously from a rumino-reticular sustained release device was prophylactically effective in preventing establishment of nine nematode parasite species in multiply-exposed cattle. Ivermectin dosages which permitted ⩽1% of infected control calf worm populations to establish ranged from <2.5 μg kg −1 day −1, which totally prevented infection with Dictyocaulus viviparus and Oesophagostomum radiatum, to ≅30 μg kg −1 day −1 required to suppress Nematodirus helvetianus to the same extent. Between these extremes, in decreasing order of sensitivity to enterical sustained release ivermectin, were Ostertagia ostertagi, Trichostrongylus axei, Haemonchus placei, Copoperia punctata, C. oncophora and T. colubriformis which were maximally affected at ⩽10 μg kg −1 day −1 of ivermectin.
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