Abstract

Literature documents the impact of Parkinson’s Disease (PD) on speech but no study has analyzed in detail the importance of the distinct phonemic groups for the automatic identification of the disease. This study presents new approaches that are evaluated in three different corpora containing speakers suffering from PD with two main objectives: to investigate the influence of the different phonemic groups in the detection of PD and to propose more accurate detection schemes employing speech. The proposed methodology uses GMM-UBM classifiers combined with a technique introduced in this paper called phonemic grouping, that permits observation of the differences in accuracy depending on the manner of articulation. Cross-validation results reach accuracies between 85% and 94% with AUC ranging from 0.91 to 0.98, while cross-corpora trials yield accuracies between 75% and 82% with AUC between 0.84 and 0.95, depending on the corpus. This is the first work analyzing the generalization properties of the proposed approaches employing cross-corpora trials and reaching high accuracies. Among the different phonemic groups, results suggest that plosives, vowels and fricatives are the most relevant acoustic segments for the detection of PD with the proposed schemes. In addition, the use of text-dependent utterances leads to more consistent and accurate models.

Highlights

  • Parkinson’s Disease (PD) is a chronic condition caused by the gradual death of brain cells, including those located in the substantia nigra, implicated in the production of dopamine

  • The results of the cross-validation (k-folds) and cross-corpora trials are expressed in terms of accuracy (%) ± Confidence Interval (CI)[44], Area Under the ROC Curve (AUC), sensitivity and specificity

  • A phonemic grouping based on manner of articulation was applied to the parkinsonian corpora or to the UBM corpus (Albayzin), enabling the observation of changes in accuracy and AUC depending on the employed phonemic manner category

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Summary

Objectives

One of the goals of this study is to identify the speech segments that are more relevant in automatic detection systems, serving as well to determine more appropriate speech tasks to be employed in this detection

Methods
Results
Discussion
Conclusion

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