Phomopsinones A–D: Four New Pyrenocines from Endophytic Fungus Phomopsis sp.

Abstract

AbstractThe structural elucidation of the compounds isolated from the endophytic Phomopsis sp. revealed phomopsinones A–D (1–4), four new α‐pyrone derivatives. Three known compounds were also isolated, namely two phomosines, phomosine A (5) and phomosine C (6), and ergosterol (7). The structures of these compounds were determined by spectroscopic analysis (1H, 13C, 1H–1H COSY, HMQC, HMBC, and ROESY NMR, and mass spectrometry), supported by molecular modeling. The absolute configurations of the new compounds 1–4 were determined by circular dichroism spectroscopy and TDDFT calculations. Preliminary studies indicated that compounds 1 and 4 show strong and good antifungal activity, respectively. Similarly, compounds 2 and 3 showed good antifungal and moderate antibacterial activities as well as antialgal activities.