PHOLIDOTA CHINENSIS ALLEVIATES AZOXYMETHANE/DEXTRAN SULFATE SODIUM-INDUCED COLORECTAL CARCINOGENESIS THROUGH INHIBITION OF TLR4 AND COX-2

Abstract

Inflammatory bowel disease (IBD) always progresses to colorectal cancer (CRC) which is the second most frequent cause of death by cancer. It is about 
 2% of population in the lifetime worldwide who at the risk for development of CRC. Oxaliplatin is an effective anticancer drug used for the treatment of advanced CRC, however, it always causes a robust painful neuropathy. Pholidota chinensis is a Chinese folk herbal medicine which was used for treatment of inflammation such as gastroenteritis, duodenal ulcer and bronchitis. In the present study, we examined the role of Pholidota chinensis in inflammation-related colon tumorigenesis which was induced by azoxymethane (AOM)/dextran sulfate sodium (DSS) in mice. We found that Pholidota chinensis can alleviate the colon tumorigenesis. The prevention effects of Pholidota chinensis is similar to oxaliplatin. Specifically, administration of Pholidota chinensis solution suppresses the expression of the proliferating cell nuclear antigen (PCNA), toll-like receptor 4 (TLR4) and cyclooxygenase-2 (COX-2). Our findings suggested that Pholidota chinensis participate in the regulation of colon cancer development through inhibiting the expression of TLR4 and COX-2.