Phitosomin drug and its use in poultry farming

Abstract

Solving the problem of normalizing metabolic processes and the morphological and functional state of the liver in poultry through the use of pharmacological agents seems to be an important reserve for increasing the effi ciency of industrial poultry farming and food production. Promising in this regard are studies on the development of medicines based on plant resources, which are characterized by structural diversity, multifunctionality of pharmacological action and low toxicity. The purpose of the research was to develop the liposomal drug Phitosomin, study its pharmacological and toxicological properties and substantiate the eff ectiveness of its use in poultry farming. Biopharmaceutical research has been carried out to develop a liposomal drug for veterinary use with a multifunctional pharmacological eff ect. The component composition of the drug Phitosomin represented by lecithin, dihydroquercetin, extracts of milk thistle, common agrimony and hare’s-ear, has been substantiated. A liposomal dosage form of the drug has been developed. Its physicochemical properties and shelf life have been established. The toxicological characteristics of the drug Phitosomin were studied, which made it possible to determine the degree of safety of its use in rearing of broiler chickens. Data were obtained experimentally on the pharmacological eff ects of Phitosomin on laboratory animals and broiler chickens when modeling various pathologies. The pharmacodynamic eff ect of the drug on blood parameters and productive traits of broiler chickens has been established, and the eff ective dose of its use in rearing broiler chickens has been determined. It was established as a result of the production inspection that when Phitosomin was introduced into the main diet of poultry of the experimental group at a dose of 5 g/kg of feed during the growth and finishing periods of feeding, there was an increase in the live weight of broiler chickens by 12,6 % and the livability of livestock by 1,6 abs.% compare with the control group.