Philadelphia-negative acute myeloid leukemia with new chromosomal abnormalities developing after first-line imatinib treatment for chronic phase chronic myeloid leukemia.

Abstract

American Journal of HematologyVolume 83, Issue 9 p. 755-755 LetterFree Access Philadelphia-negative acute myeloid leukemia with new chromosomal abnormalities developing after first-line imatinib treatment for chronic phase chronic myeloid leukemia Carmen Fava, Carmen Fava Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TexasSearch for more papers by this authorJorge Cortes, Jorge Cortes Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TexasSearch for more papers by this author Carmen Fava, Carmen Fava Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TexasSearch for more papers by this authorJorge Cortes, Jorge Cortes Department of Leukemia, University of Texas, MD Anderson Cancer Center, Houston, TexasSearch for more papers by this author First published: 27 May 2008 https://doi.org/10.1002/ajh.21230Citations: 4AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat References 1 Deininger MW,Cortes J,Paquette R, et al. The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in Philadelphia chromosome-negative cells. Cancer 2007; 110: 1509– 1519. 2 Jabbour E,Kantarjian HM,Abruzzo LV, et al. Chromosomal abnormalities in Philadelphia chromosome negative metaphases appearing during imatinib mesylate therapy in patients with newly diagnosed chronic myeloid leukemia in chronic phase. Blood 2007; 110: 2991– 2995. 3 Perel JM,McCarthy C,Walker O, et al. Clinical significance of development of Philadelphia-chromosome negative clones in patients with chronic myeloid leukemia treated with imatinib mesylate. Haematologica 2005; 90 Suppl: ECR25. 4 Kovitz C,Kantarjian H,Garcia-Manero G, et al. Myelodysplastic syndromes and acute leukemia developing after imatinib mesylate therapy for chronic myeloid leukemia. Blood 2006; 108: 2811– 2813. 5 Quintas-Cardama A,Kantarjian H,Abruzzo LV,Cortes J. Extramedullary BCR-ABL1-negative myeloid leukemia in a patient with chronic myeloid leukemia and synchronous cytogenetic abnormalities in Philadelphia-positive and -negative clones during imatinib therapy. Leukemia 2007; 21: 2394– 2396. 6 Pawarode A,Sait SN,Nganga A, et al. Acute myeloid leukemia developing during imatinib mesylate therapy for chronic myeloid leukemia in the absence of new cytogenetic abnormalities. Leuk Res 2007; 31: 1589– 1592. 7 Jin Huh H,Won Huh J,Myong Seong C, et al. Acute lymphoblastic leukemia without the Philadelphia chromosome occurring in chronic myelogenous leukemia with the Philadelphia chromosome. Am J Hematol 2003; 74: 218– 220. 8 Cherrier-De Wilde S,Rack K,Vannuffel P, et al. Philadelphia-negative acute lymphoblastic leukemia developing in a CML patient in imatinib mesylate-induced complete cytogenetic remission. Leukemia 2003; 17: 2046– 2048. 9 Melani C,Canepa L,Sessarego M, et al. Molecular analysis of the bcr rearrangement in a case of Ph'-negative blastic crisis of Ph'-positive chronic myelogenous leukemia. Eur J Haematol 1989; 42: 32– 37. 10 Baer MR,Bloomfield CD. Trisomy 13 in acute leukemia. Leuk Lymphoma 1992; 7: 1– 6. Citing Literature Volume83, Issue9September 2008Pages 755-755 ReferencesRelatedInformation