Phenytoin as an augmentation for SSRI failures: A small controlled study

Abstract

Background Lithium augmentation of antidepressant effects in patients unimproved on antidepressants is well documented. We hypothesized that phenytoin, reported to have antimanic, antidepressant and prophylactic effects on affective disorder, might also augment in SSRI failures. Methods Twenty five patients were recruited and twenty had data sufficient for analysis between phenytoin and placebo in depression ratings. Results No effect was found. Limitations This study was a small study. Conclusions Lithium's ability to augment in antidepressant failures may not be shared with the anticonvulsant mood stabilizers.