Abstract
The pharmacokinetics of phenytoin (PHT) before and after administration of 1 and 5 mg of folic acid is reported from the Colleges of Pharmacy and Medicine, University of Iowa, Iowa City and University of Health Sciences/The Chicago Medical School, Chicago, IL.
Highlights
PHENYTOIN AND FOLIC ACID The pharmacokinetics of phenytoin (PHT) before and after administration of 1 and 5 mg of folic acid is reported from the Colleges of Pharmacy and Medicine, University of Iowa, Iowa City and University of Health Sciences/The Chicago Medical School, Chicago, IL
The measured total serum PHT concentration was always greater than the calculated concentration and the days to the steady state concentration were always longer than the number calculated before folic acid was given
The authors suggest that folic acid should be prescribed when phenytoin therapy is initiated
Summary
CARBAMAZEPINE ACUTE TOXICITY The clinical toxic effects and serum concentrations after ingestion of carbamazepine are reported in 82 pediatric patients from the Intensive Care Unit, Royal Children's Hospital, Melbourne, Australia. PHENYTOIN AND FOLIC ACID The pharmacokinetics of phenytoin (PHT) before and after administration of 1 and 5 mg of folic acid is reported from the Colleges of Pharmacy and Medicine, University of Iowa, Iowa City and University of Health Sciences/The Chicago Medical School, Chicago, IL. The measured total serum PHT concentration was always greater than the calculated concentration and the days to the steady state concentration were always longer than the number calculated before folic acid was given.
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