Abstract

Two derivatives of phenyltrisalanine, a new, trifunctional amino acid, were synthesised in optically active forms. Two complementary techniques were employed, an HWE olefination reaction or a Heck coupling reaction, and the resulting dehydroamino acids were hydrogenated using a chiral Rh(I)–Et-DuPHOS catalyst. Phenyltrisalanine derivatives of excellent stereoisomeric purities were thus obtained.

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