Abstract
Phenylethanoid glycosides (PhGs) are widely distributed in traditional Chinese medicines as well as in other medicinal plants, and they were characterized by a phenethyl alcohol (C6-C2) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond. The outstanding activity of PhGs in diverse diseases proves their importance in medicinal chemistry research. This review summarizes new findings on PhGs over the past 10 years, concerning the new structures, their bioactivities, including neuroprotective, anti-inflammatory, antioxidant, antibacterial and antivirus, cytotoxic, immunomodulatory, and enzyme inhibitory effects, and pharmacokinetic properties.
Highlights
Phenylethanoid glycosides (PhGs) are a class of water-soluble compounds widely distributed in traditional Chinese medicines (TCMs), as well as other medicinal plants
PhGs are characterized by a phenethyl alcohol (C6 -C2 ) moiety attached to a β-glucopyranose/β-allopyranose via a glycosidic bond
The results showed that the latency of step down was shortened in Alzheimer’s disease (AD) model mice and the number of errors decreased after treatment with all doses of 121
Summary
Phenylethanoid glycosides (PhGs) are a class of water-soluble compounds widely distributed in traditional Chinese medicines (TCMs), as well as other medicinal plants They have been detected in roots, stems, leaves, flowers, fruits and seeds without organ selectivity, while their concentrations in each organ may vary a lot [1,2]. Interest in PhGs has been growing, with a significantly increasing volume of literature describing PhGs1 novel structures, diverse bioactivities, and evident roles in the prevention and treatment of various human diseases as well as their pharmacokinetics having been reported Such rich information prompted us to review papers on novel PhG structures, their pharmacological activities and pharmacokinetics published in the last decade
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