Phenylethanoid and secoiridoid glycosides from the leaves of Ligustrum purpurascens

Abstract

A new phenylethanoid glycoside (2) and a new secoiridoid glycoside (16) were isolated from the leaves of Ligustrum purpurascens together with fourteen known compounds (1 and 3–15). The structures of the new compounds were determined by spectroscopic analyses (UV, IR, HR-ESI-MS, 1D, and 2D NMR). The absolute configuration of 16 was further determined by CD analysis. All phenylethanoid glycosides were prepared and their up-regulation of IFN-γ production in mouse splenic lymphocytes was evaluated. Compounds 1, 5, 6, 10, 11, 13 and 15 exhibited potent stimulatory effect on IFN-γ secretion.