Phenyl group as a probe in the 1H nuclear magnetic resonance study of the conformations of quaternary heteroaromatic carbapenem antibiotics. Identification of the site of quaternization in -SCH2- substituted nitrogen-containing heteroaromatic derivatives

Abstract

The phenyl group is shown as a useful probe in sensing the environment in the 1H nuclear magnetic resonance conformational study of a variety of quaternary heteroaromatic carbapenem derivatives. The influence of the -SCH2- substituent in determining the site of quaternization in nitrogen-containing heteroaromatic compounds is demonstrated through the acidity measurements of these methylene protons.