Abstract
Zavada's (1972a) demonstration that vesicular stomatitis virus (VSV) can form pseudotypes bearing the envelope antigens of avian myeloblastosis virus or murine leukemia virus prompted us to investigate the formation and properties of phenotypically mixed virus particles following mixed infection of VSV and various strains of avian RNA tumor virus (ATV). We have found that the host range in avian cells of the VSV pseudotypes was restricted to that of the ATV strain used, and that the infectivity of the pseudotype is subject to specific interference by avian leukemia viruses belonging to the same subgroup and to neutralization by anti-sera specific to the leukemia virus. These properties of VSV pseudotypes have enabled us to use them to investigate (1) the role of the envelope in the tropism of different strains of ATV for mammalian cells, (2) the detection of envelope components coded by endogenous viral genes where complete virus is not...
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