Abstract
Event-related brain potentials (ERPs) are a noninvasive method of measuring brain activity during cognitive processing. ERPs provide an insight into very early stages of information processing. Because of their high temporal resolution, noninvasiveness, relatively low cost, and ability to provide a continuous measure of the brain’s information processing, ERPs have been widely adopted by scientists to study normal cognitive processing and functions at different developmental stages, as well as to illuminate how and why these cognitive processes are altered in neurological and psychiatric disorders. A number of ERPs have been identified as intermediate markers or endophenotypes for psychiatric illnesses. This chapter selectively describes six ERP measures that are commonly studied in neuropsychiatric disorders. Each measure may be useful in diagnosis prediction, identifying genetic susceptibility, understanding cognitive behavior and brain function, and as biomarkers for drug discovery.
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