Abstract
BackgroundThis study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients.MethodsWe prospectively recruited patients between 20 and 80 years of age who had nodular BE type NTM lung disease. Phenotypic, immunologic, and clinical characteristics were evaluated through physical examination, laboratory tests, pulmonary function tests, and radiographic examinations. Questionnaires were also answered. The results of the evaluations were compared with the results of non-NTM BE patients.ResultsA total of 84 patients with NTM lung disease and 47 non-NTM BE patients participated in the study. Mycobacterium avium complex lung disease and M. abscessus lung disease were most common. Patients with NTM lung disease had lower body mass index than non-NTM BE patients. Scoliosis was observed more frequently in patients with NTM lung disease than in non-NTM BE patients.ConclusionsSignificant similarities were seen between Korean patients with NTM lung disease and patients from other countries. Differences in phenotypic and clinical characteristics between NTM lung disease and non-NTM BE patients suggest differences in the immunopathogenesis of NTM lung disease and non-NTM BE.Trial registration informationClinicalTrials.gov Registration number; NCT01616745
Highlights
This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients
Patient characteristics A total of 127 patients with NTM lung disease were enrolled in the study, with eight patients withdrawing consent prior to study completion
84 patients with nodular BE type NTM lung disease were included in the study
Summary
This study aimed to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with nontuberculous mycobacterial (NTM) lung disease and compare them with non-NTM bronchiectasis (BE) patients. Rates of NTM isolation, as well as the number of patients with NTM lung disease, have been increasing worldwide [1]; the fact that only a small number of people contract NTM despite ubiquitous exposure suggests the presence of identifiable risk factors associated with NTM infection. While the immunopathogenesis of NTM lung disease remains largely unknown, certain phenotypic and immunologic characteristics of patients with NTM lung disease have been observed. The aim of this study was to elucidate the phenotypic, immunologic, and clinical characteristics of Korean patients with NTM lung diseases through comparisons with non-NTM bronchiectasis (BE) patients
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