Abstract
Background: Carbapenem-resistant Enterobacteriaceae (CRE) pose a great threat to the public health sector as a result of its high communicability, high morbidity and mortality rates. This study investigated the occurrence of carbapenem resistant Enterobacteriaceae and the prevalence of Klebsiella pneumoniae carbapenemase (KPC) producing Klebsiella pneumoniae as a mechanism of resistance. Method: One hundred and ten Enterobacteriaceae isolates were cultured from different samples of patients in Intensive Care Units of two hospitals. Using Clinical and Laboratory Standards Institute (CLSI) Guidelines of 2017. Carbapenemase production was determined phenotypically using Brilliance CRE agar, Carbapenem inactivation method and confirmed with Modified Hodge test (MHT). Modified Hodge test positive isolates were screened for KPC-producing Klebsiella pneumoniae using boronic acid-based inhibition test. Result: Phenotypic results revealed an occurrence of 10.9% (12/110) isolates for carbapenem resistant Enterobacteriaceae while KPC-producing Klebsiella pneumoniae prevalence was 3.6% contributing 33.3% to the burden of carbapenem production. The occurrence of carbapenem-resistant Enterobacteriaceae in this study was relatively high and KPC-Klebsiella pneumoniae had a significant contribution to the burden of CRE. Conclusion: Hence, a sinewy antibiotic stewardship is needed in this regard.
Highlights
Carbapenem-resistant Enterobacteriaceae (CRE) are highly pathogenic and antibiotic-resistant Gram negative organisms producing nosocomial infections because of its innate capacity for fast transmission within healthcare facilities and its environs [1]
This study investigated the occurrence of carbapenem resistant Enterobacteriaceae and the prevalence of Klebsiella pneumoniae carbapenemase (KPC) producing Klebsiella pneumoniae as a mechanism of resistance
Brilliance CRE agar revealed 12 isolates were positive for carbapenem production while Carbapenem inactivation method (CIM) had 11 positive isolates for carbapenem production (Table 1)
Summary
Carbapenem-resistant Enterobacteriaceae (CRE) are highly pathogenic and antibiotic-resistant Gram negative organisms producing nosocomial infections because of its innate capacity for fast transmission within healthcare facilities and its environs [1]. Carbapenem-resistant Enterobacteriaceae pose a great threat to the public health sector due to its high rate of transmission which causes high morbidity and mortality coupled with very minute chances of treatment [3,4]. Carbapenemase-producing Enterobacteriaceae (CPE) are predominant in the clinical isolates of CRE where there is high burden of CRE [6]. Carbapenem-resistant Enterobacteriaceae (CRE) pose a great threat to the public health sector as a result of its high communicability, high morbidity and mortality rates. Result: Phenotypic results revealed an occurrence of 10.9% (12/110) isolates for carbapenem resistant Enterobacteriaceae while KPC-producing Klebsiella pneumoniae prevalence was 3.6% contributing 33.3% to the burden of carbapenem production. The occurrence of carbapenem-resistant Enterobacteriaceae in this study was relatively high and KPCKlebsiella pneumoniae had a significant contribution to the burden of CRE. Conclusion: a sinewy antibiotic stewardship is needed in this regard
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