Abstract
Understanding phenotypic characteristics of the diabetic kidney is important to developing therapies to prevent progression of diabetic nephropathy. In addition to glomerular hyperfiltration and kidney growth, major metabolic abnormalities characterize the diabetic kidney. Increased kidney oxygen consumption leads to cortical and medullary hypoxia in diabetes. Decreasing inspired oxygen to 10% reduces pO2 while oxygen consumption remains elevated while lactate increases and the redox potential decreases but only in diabetic kidney, a shift to Warburg metabolism.
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