Abstract
Purpose: TissueGene C (TG-C) is a cell-mediated gene therapy for knee osteoarthritis (OA) that is administered through a single intra-articular injection. It is composed of a 3:1 mixture of non-irradiated allogeneic human chondrocytes (hChonJ) and irradiated and transduced human GP2-293 cells, a protein production platform used for over-expressing transforming growth factor (TGF)-β1, a growth factor that promotes cell differentiation and anti-inflammatory activity. The aim of this study was to examine the phenotypic characteristics and gene expression profile of the hChonJ component of TG-C and compare the expression of chondrogenic genes and cell surface markers in hChonJ with the chondrocyte cell line C28/I2 and commercially available primary human chondrocytes from late passage cultures.
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