Abstract
Glaucoma is one of the leading causes of blindness, and there is an ongoing need for new therapies. Recent studies indicate that cell transplantation using Müller glia may be beneficial, but there is a need for novel sources of cells to provide therapeutic benefit. In this study, we have isolated Müller glia from retinal organoids formed by human induced pluripotent stem cells (hiPSCs) in vitro and have shown their ability to partially restore visual function in rats depleted of retinal ganglion cells by NMDA. Based on the present results, we suggest that Müller glia derived from retinal organoids formed by hiPSC may provide an attractive source of cells for human retinal therapies, to prevent and treat vision loss caused by retinal degenerative conditions. stem cells translational medicine 2019;8:775&784
Highlights
Glaucoma is one of the leading causes of blindness throughout the world [1]
Based on the present results, we suggest that Müller glia derived from retinal organoids formed by human induced pluripotent stem cells (hiPSCs) may provide an attractive source of cells for human retinal therapies, to prevent and treat vision loss caused by retinal degenerative conditions
Based on the present results, we propose that Müller glia derived from retinal organoids formed by hiPSC may provide an attractive source of cells for human retinal therapies, to prevent and repair vision loss caused by retinal degenerative conditions such as glaucoma
Summary
Glaucoma is one of the leading causes of blindness throughout the world [1]. It is characterized by high intraocular pressure, gradual loss of retinal ganglion cells (RGCs) and optic nerve damage [2, 3]. Müller glia with stem cell characteristics were first identified in the zebrafish [4], in which they are responsible for the complete regeneration of the adult retina after injury [5, 6]. In this species, Müller glia re-enter the cell cycle to generate multipotent progenitors that proliferate, migrate, and differentiate into most neural cell types [7], that restore retina function [8]. A population of Müller glia isolated from the adult human retina has been shown to have stem cell
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