Abstract

Established lymphoblastoid cell lines with natural killer cell-like activity have been derived from cattle and deer affected with malignant catarrhal fever. They were examined phenotypically using monoclonal antibodies chosen for their cross-reactivity with peripheral blood lymphocytes from these species. Cell lines established from three of four cattle were identified as cytotoxic/suppressor lymphocytes (CD4 -/CD8 +/T19 -) whilst the other was shown to be of the helper cell phenotype (CD4 +/ CD8 − /T19 −). Two other cell lines, one derived from a red deer and the other from a Pére David's deer, were both CD4 -/CD8 -/T19. All of the lines examined expressed a T cell receptor (CD2 +).

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