Abstract
Enzymes of the Nudix Hydrolase superfamily are characterized by the ability to hydrolyze substrates containing nucleoside diphosphate linked to some moiety x, hence the acronym Nudix. We are systematically analyzing the E. coliNudix hydrolase knockouts for phenotypes. MutT is an established antimutator, and we have determined that the other Nudix hydrolases from E. coli are not antimutators. Complementation studies with Nudix hydrolases from M. tuberculosishave been carried out to determine which, if any, are antimutators; thus far, none have been determined to be antimutators. We also screened the E. coli Nudix hydrolase knockouts for antibiotic susceptibility with mixed results that are being analyzed further.
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