Abstract
Aim. To study the main risk factors and signs of connective tissue dysplasia (CTD) in young people according to quartile analysis of cardioankle vascular index (CAVI).Material and methods. The study involved 243 young people (men, 81; women, 162) aged 18-25 years. All subjects were divided into quartile groups depending on CAVI on both sides, or CAVI-R and CAVI-L, determined using the VaSera-1500 system (Fucuda Denshia,Japan). According to the latest guidelines, the 4th quartile of this distribution among persons of the same sex and age corresponds to early vascular aging (EVA) syndrome. The 1st quartile corresponds to favorable vascular aging. We analyzed the main RFs and CTD signs in each of the 4 CAVI quartiles. Data processing was carried out using the Statistica 10.0 software package (StatSoft Inc,USA).Results. The minimum and maximum CAVI in the sample were 3,2 and 7,9. The overwhelming majority of studied risk factors in both sexes were not associated with the stiffness. Only body mass and body mass index increasedwith a decrease in vascular stiffness and vice versa. The average number of external stigmas of dysembryogenesis in young people increased from the 1st to the 4th CAVI quartile, with significant differences in the extreme groups. Such CTD signs as a carpal tunnel syndrome and thumb sign also significantly differed between the 1st and 4th quartiles.Conclusion. The presented results can be used for prevention among young people to form more individualized programs taking into account a comprehensive assessment of vascular aging phenotype and the level of external stigmatization of each young person.
Highlights
Phenotypes of early and favorable vascular aging in young people depending on the risk factors and presence of connective tissue dysplasia
Takaki A, Ogawa H, Wakeyama T, et al Cardio-ankle vascular index is superior to brachialankle pulse wave velocity as an index of arterial stiffness
Summary
Изучить основные факторы риска и внешние признаки дисплазии соединительной ткани (ДСТ) у лиц молодого возраста с позиций квартильного анализа показателя сосудистой жесткости (СЖ) CAVI (cardio-ankle vascular index). Н. — ассистент кафедры факультетской терапии, ORCID: 0000-0001-8636-0987, Русиди А. В. — ассистент кафедры факультетской терапии, ORCID: 0000-0002-3690-3020, Галькова И. Ю. — ассистент кафедры факультетской терапии, ORCID: 0000-0002-3381-1710, Кудрявцева В. АД — артериальное давление, ДСТ — дисплазия соединительной ткани, ИМТ — индекс массы тела, ЛМВ — лица молодого возраста, МТ — масса тела, ОХС — общий холестерин, СРПВ — скорость распространения пульсовой волны, СЖ — сосудистая жесткость, ССЗ — сердечно-сосудистые заболевания, ТГ — триглицериды, ФР — факторы риска, ХС ЛВП — липопротеины высокой плотности, ХС ЛНП — липопротеины низкой плотности, CAVI — cardio-ankle vascular index (сердечно-сосудистый индекс), EVA — early vascular aging (синдром преждевременного старения). Цель — изучить основные ФР и внешние признаки ДСТ у лиц молодого возраста (ЛМВ) с позиций квартильного анализа показателя СЖ CAVI
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