Abstract

The nature and origin of Reed-Sternberg and Hodgkin cells (HD) are still obscure. Their origin in a normal counterpart has been attributed to most cells of the hematopoietic lineage. Evidence has been reported suggesting a descent from, for example, macrophages/histiocytes (1–5) T-lymphoid cells (6,7), B-lymphoid cells (8,9), myeloid progenitor cells (10), dendritic reticulum cells (11,12), interdigitating reticulum cells (13), and from a newly detected small-cell population, bearing the Ki-1 antigen (14). We have studied cell suspensions of different malignant lymphomas, obtained by needle aspiration or biopsy, with a panel of monoclonal antibodies (mAbs). Here we want to report the reaction pattern of five cases with histologically proven Hodgkin’s disease.

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