Abstract
THE NEUROLOGICAL syndromes due to phenothiazines, consisting of dystonia, akathisia, and a parkinsonian state, have been frequently described. 1-4 Symptoms of phenothiazine toxicity are known to be more marked in infants and young adults, and they also occur with more frequency in patients in a toxic condition and in dehydrated and febrile patients. 3 There is little mention in the literature of reactions which produce spasticity and pathological reflexes. One such case, reported by Swaiman, 5 concerns a widely used and relatively safe phenothiazine, promethazine hydrochloride, which caused marked central-nervous-system depression, hyperreflexia and Babinski's sign on both sides in a dehydrated child. We have seen similar patients whom we feel developed such neurological symptoms and signs as a result of a reaction to phenothiazines. Report of Cases Case 1.— An 8-year-old white boy was admitted because of two days of lethargy, anorexia, and vomiting, and several hours of irrational behavior,
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