Abstract
The characteristics of holistic, dynamics, complexity, and spatial and temporal features enable “Omics” and theories of TCM to interlink with each other. HPO, namely, “characterization,” can be understood as a sorting and generalization of the manifestations shown by people with diseases on the basis of the phenomics. Syndrome is the overall “manifestation” of human body pathological and physiological changes expressed by four diagnostic methods' information. The four diagnostic methods' data could be the most objective and direct manifestations of human body under morbid conditions. In this aspect, it is consistent with the connation of “characterization.” Meanwhile, the four diagnostic methods' data also equip us with features of characterization in HPO. In our study, we compared 107 pieces of four diagnostic methods' information with the “characterization database” to further analyze data of four diagnostic methods' characterization in accordance with the common characteristics of four diagnostic methods' information and characterization and integrated 107 pieces of four diagnostic methods' data to relevant items in HPO and finished the expansion of characterization information in HPO.
Highlights
Since the early 1990s, “omics” began to emerge in the field of life sciences as the most compelling concept, including genomics, proteomics, transcriptomics, and metabolomics
We selected 385 CHD cases with Unstable angina pectoris TP (UAP) admitted by Dongzhimen Hospital, which is the affiliated hospital of Beijing University of Chinese Medicine, China-Japan Friendship Hospital, Beijing Anzhen Hospital, Zhengzhou Hospital of Traditional Chinese Medicine, Wuhan Hospital of Traditional Chinese Medicine, and Hubei Hospital of Traditional Chinese Medicine, from May 2009 to March 2011
The diagnostic criteria of angina pectoris was referred to the Treatment Guidelines Chronic Stable Angina (1999) jointly identified by American College of Cardiology (ACC)/American Heart Association (AHA)/American College of Physicians and the American Society of Internal Medicine ACP-ASIM [13], and the Diagnosis and Treatment Recommendations of Unstable Angina made by Chinese Medical Society of Cardiology in 2000 [14]
Summary
Since the early 1990s, “omics” began to emerge in the field of life sciences as the most compelling concept, including genomics, proteomics, transcriptomics, and metabolomics. The holistic and systematic ideology of TCM is reflected at a macro level, while the omics technology is the reintegration based on comprehensive analysis and restoration. Omics technology helps to quantify, objectify, and standardize TCM theory and further provides a new platform to evidence-based researches on TCM theories. Phenome refers to all the phenotypes of a cell or an organism, whose life activities are reflected through phenotypes. Phenomics is a subject studying all phenotypes of an organism or a cell in various conditions at the genomic level [1, 2]. Sensitive Phenomics research tools can reveal a number of intermediate phenotypes which are previously unknown, and they are expected to be applied to the treatment of diseases [3]
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