Abstract
BackgroundScedosporium species are a group of pathogenic fungi, which can be found worldwide around high human-impacted areas. Infections of Scedosporium have been reported in several immunocompromised and immunocompetent patients with a high mortality rate. Recently, we have isolated and identified several Scedosporium strains during an environmental survey in Thailand.ResultsWe describe the isolate, TMMI-012, possibly a new species isolated from soils in the Chatuchak public park, Bangkok, Thailand. TMMI-012 is phylogenetically related to the Scedosporium genus and is a sibling to S. boydii but shows distinct morphological and pathological characteristics. It is fast growing and highly resistant to antifungal drugs and abiotic stresses. Pathological studies of in vitro and in vivo models confirm its high virulence and pathogenicity.ConclusionTMMI-012 is considered a putative novel Scedosporium species. The high antifungal resistance of TMMI-012 compared with its sibling, Scedosporium species is likely related to its clinical impact on human health.
Highlights
Scedosporium species are a group of pathogenic fungi, which can be found worldwide around high human-impacted areas
TMMI-012, possibly a new species isolated from soils in the Chatuchak public park, Bangkok, Thailand
TMMI-012 isolates a probable new sibling species to Scedosporium boydii Since our reports on the environmental survey of S. apiospermum species complex in Bangkok [21, 23] and other six geographic regions in Thailand [22], we have collected and identified Scedosporium isolates using multi-locus sequence typing (MLST) sequencing technique in which sequences are amplified at eight genetic loci: actin (ACT), CAL, RPB2, manganese superoxide dismutase (SOD2), internal transcribed spacer (ITS), transcription elongation factor 1α (TEF-1α), TUB, and BT2 [21,22,23]
Summary
Scedosporium species are a group of pathogenic fungi, which can be found worldwide around high human-impacted areas. Infections of Scedosporium have been reported in several immunocompromised and immunocompetent patients with a high mortality rate. We have isolated and identified several Scedosporium strains during an environmental survey in Thailand. Scedosporium species have been isolated around high humanimpacted areas, such as public parks and industrial sites [1]. Scedosporium species can be found worldwide and cause a broad range of clinical manifestations in immunocompromised and immunocompetent patients, from localized infections to systemic mycoses, especially in the skin, lungs, and brain [3,4,5,6,7,8]. Patients with brain abscess and disseminated disease from Scedosporium infections are often at higher risk [13]
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