Phenols as an alternative, neuroprotective, and preventive strategy for Alzheimer's disease: (mini-review and bibliometric analysis)

Abstract

Objective: This study aimed to perform a bibliometric review focused on secondary metabolites of phenolic origin in the context of Alzheimer's disease. Analyzing the research trend in this field during the last two decades, highlighting the chemical-computational (in silico) perspective Design/methodology/approach: Publications from the last two decades (2001-2023) were examined using the academic search engine Dimensions. The focus of our analysis was on identifying co-occurrence networks of terms present in the titles and abstracts of these publications, setting a minimum threshold of 100 co-occurrences for inclusion in the study (VOSviewer v. 1.6.19,2023). Results: The literature consulted suggests phenolic compounds as metabolites with preventive capacity, derived from their antioxidant, anti-inflammatory, and neuroprotective properties. Limitations on study/implications: However, it is essential to highlight the limitations observed in each area so that an integral vision is encouraged in future research. Findings/conclusions: The integration of epidemiological studies, in vitro investigations, in silico análisis, and in vivo experiments will advance the development of therapeutic strategies based on phenolic compounds for the care of multifactorial Alzheimer's disease.