Abstract
Thisstudysoughttocharacterizetheinteractionof phenolicextractfromgrapefruit peels with a-amylase, a-glucosidase and angiotensin-I-converting enzyme (ACE) activities.Thefreephenolicofgrapefruitpeelswasextractedwith80%acetone,while theboundphenolicwasextractedfromthealkalineandacid-hydrolyzedresiduewith ethyl acetate; and their interaction with the enzymes were assessed. The phenolic extractsinhibited a-amylase,a-glucosidaseandACEenzymeactivities;however,free phenolichadsignificantlyhigher(P 0.05)in their ACE inhibitory activities. Nevertheless, the extracts were strong inhibitor of a-glucosidase when compared to a-amylase. The phenolic inhibited sodium nitroprusside-induced lipid peroxidation in pancreas in a dose-dependent manner. Therefore, free and bound phenolic extracts from grapefruit peels could be used as nutraceuticalforthemanagementofhypertensionandtype2diabetes.
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