Abstract
The total phenolic content, antioxidant, antimicrobial and cytotoxic activities of hot ethanolic extract of Salix alba bark were investigated. The antioxidant properties and the total phenolic contents of the extract were assessed by 1, 1-Diphenyl- 2-Picrylhydrazyl (DPPH) free radical scavenging and Folin-Ciocalteu methods, respectively. The extract showed significant antioxidant activity and antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. The highest effect was observed on C. albicans, followed by S. aureus then P. aeruginosa. While, Escherichia coli and Klebsiella pneumoniae were not affected. The cytoxicity of S. alba extract against the Human Leukemia (HL-60) cell line was evaluated, it had been noticed that the extract significantly reduced the viability of HL-60 cells in a dose- and time-dependent response relationship. Findings from the present study indicate that extract is highly cytotoxic to HL-60 cells. The antimicrobial and cytotoxic activities of S. alba extract seemed to be positively correlated with their antioxidant potentials.
Highlights
Since the beginnings of civilization, humans have used natural products for healing diseases that afflict them
The highest effect was observed on C. albicans, followed by S. aureus P. aeruginosa
The antimicrobial and cytotoxic activities of S. alba extract seemed to be positively correlated with their antioxidant potentials
Summary
Since the beginnings of civilization, humans have used natural products for healing diseases that afflict them. Plants are biochemical labs that produce inside their cells a variety of complex substances with numerous active compounds. With the advent of the pharmaceutical chemistry at the beginning of the nineteenth century, plants became the primary source of substances for drug development (Rates, 2001). White willow (Salix alba L.), is a willow belongs to the genus salix and family salicaeae. Willows range from prostrate shrubs to large tree over 30 m high, but most are shrubs or small trees. White willow which is known as the salicin willow, has been used for its health benefits for thousands of years (Saller et al, 2008)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: American Journal of Biochemistry and Biotechnology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
