Phenolic Constituents from Fallopia multiflora (Thunberg) Haraldson

Thi Thoa Nguyen,Van Cuong Pham,Chau Van Minh,Thanh Binh Pham,Van Hung Nguyen,Nguyen Hai Dang,Nguyen Tien Dat,Quang Hai Tran,Nguyen Phuong Thao

doi:10.1155/2018/4851439

Thi Thoa Nguyen, Van Cuong Pham + Show 7 more

Open Access

https://doi.org/10.1155/2018/4851439

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Abstract

Four naphtolic glycosides (1–4), three anthraquinones (5–7), two stilbenes (8-9), one benzyl glycoside (10), and one flavonoid (11) were isolated from the roots of Fallopia multiflora. The new compounds were elucidated to be 6-hydroxymusizin 8-O-α-D-apiofuranosyl-(1→6)-β-D-glucopyranoside (1) and 6-methoxy-3-methyl-1,6,8-trihydroxy-2-naphthoic acid 8-O-β-D-glucopyranoside (3). Compound 3 could be an important marker for chemotaxonomy of F. multiflora. Benzyl gentiobioside (10) was isolated for the first time from the family Polygonaceae.

Highlights

Fallopia multiflora Haraldson (Polygonaceae), synonym Polygonum multiflorum unb., is an important medicinal plant in Oriental medicine
Previous phytochemical investigations have revealed the presence of stilbenes and anthraquinones as major components in F. multiflora [2]. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucopyranoside, emodin, and physcion are used as main markers for quality control of F. multiflora materials and related products [3]
By means of spectroscopic methods and in comparison with the reported data, the structure of the known compounds was identified as torachrysone 8-O-β-D-glucopyranoside (2), 4′′ O 5′′ 3′′

Summary

Introduction

Fallopia multiflora ( unberg) Haraldson (Polygonaceae), synonym Polygonum multiflorum unb., is an important medicinal plant in Oriental medicine. It is grown for various medicinal values ranging from bowel relaxation, antiaging, hair loss prevention, increasing sexual vigour, treatment of high cholesterol, high blood pressure, and inflammation [1]. Previous phytochemical investigations have revealed the presence of stilbenes and anthraquinones as major components in F. multiflora [2]. 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucopyranoside, emodin, and physcion are used as main markers for quality control of F. multiflora materials and related products [3]. A phytochemical investigation of the Fallopia multiflora roots led to the isolation of two new (1 and 3) and nine known compounds (Figure 1)

Experimental

Results and Discussion

Conclusion