Abstract
Introduction: The metabolites of lichens concentrated depsidones, depsides, and diphenyl ethers were possessed antibiotic, antifungal, antiviral, antitumor, and anticancer activities. Parmotrema tinctorum (Despr. ex Nyl.) Hale, a species of foliose lichen, is widely distributed in Lam Dong province, Vietnam. Herein, this paper describes the isolation and structure elucidation of seven compounds isolated from this lichen. Methods: Phytochemical investigations of the ethyl acetate extract of the lichen P. tinctorum led to the isolation of seven pure compounds. Their chemical structures were elucidated by extensive HR-ESI-MS and NMR spectroscopic analysis and comparison with previously published data. Results: Seven compounds, namely orcinol (1), orsellinic acid (2), methyl orsellinate (3), methyl heamatomate (4), lecanorin (5), lecanoric acid (6), and gyrophoric acid (7). These compounds were determined the α-glucosidase inhibitory activity. Conclusions: Compound 7 was determined for the first time in P. tinctorum, and this was also the first time these compounds were determined the α-glucosidase inhibitory activity.
Highlights
The metabolites of lichens concentrated depsidones, depsides, and diphenyl ethers were possessed antibiotic, antifungal, antiviral, antitumor, and anticancer activities
4 For the purpose of searching for new classes of α-glucosidase inhibitors, we reported the isolation and structural elucidation of seven compounds from the ethyl acetate extract of the lichen Parmotrema tinctorum (Nyl.) Hale and the α-glucosidase inhibitory activity of these compounds
Compound 1 was isolated as colorless needles; its molecular formula was determined as C7H8O2 through its pseudo molecular ion peak at m/z 125.0602 [M+H]+ in the HR-ESI-MS spectrum
Summary
The metabolites of lichens concentrated depsidones, depsides, and diphenyl ethers were possessed antibiotic, antifungal, antiviral, antitumor, and anticancer activities. Methods: Phytochemical investigations of the ethyl acetate extract of the lichen P. tinctorum led to the isolation of seven pure compounds. Their chemical structures were elucidated by extensive HR-ESI-MS and NMR spectroscopic analysis and comparison with previously published data. Results: Seven compounds, namely orcinol (1), orsellinic acid (2), methyl orsellinate (3), methyl heamatomate (4), lecanorin (5), lecanoric acid (6), and gyrophoric acid (7) These compounds were determined the α-glucosidase inhibitory activity. 4 For the purpose of searching for new classes of α-glucosidase inhibitors, we reported the isolation and structural elucidation of seven compounds from the ethyl acetate extract of the lichen Parmotrema tinctorum (Nyl.) Hale and the α-glucosidase inhibitory activity of these compounds The development of an α-glucosidase inhibitor derived from natural products is an important contribution to the treatment of diabetes. 1,2 Parmotrema tinctorum was used as an edible spice for flavoring food in Kerela, India. 3 The methanolic extract of P. tinctorum exhibited the anti-arthritic potential on experimental rats. 4 For the purpose of searching for new classes of α-glucosidase inhibitors, we reported the isolation and structural elucidation of seven compounds from the ethyl acetate extract of the lichen Parmotrema tinctorum (Nyl.) Hale and the α-glucosidase inhibitory activity of these compounds
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